This valuable manuscript investigates the localisation of nutrient receptors in bloodstream stage trypanosomes, with implications for both nutrient uptake and immune evasion. Results after direct ...

The parasite Trypanosoma brucei can exploit antigenic variation of its VSG coat proteins to avoid detection by the mammalian host. In the December 13 Nature, Miguel Navarro and Keith Gull from the ...

T. brucei's protein disguise comes from a family of variant surface glycoproteins (VSGs). At any time, a single VSG covers the parasite and, during an infection, the parasites in the bloodstream ...

More information: Alexander K. Beaver et al, Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, ...

African trypanosomes, such as Trypanosoma brucei, are a model for this process whose genome contains more than 2,000 Variant Surface Glycoprotein (VSG) encoding genes.

A study by Johns Hopkins researchers reveals that the parasite T. brucei, responsible for African sleeping sickness, uses host tissues to evade immune responses. The findings show that T. brucei ...

To get a fuller understanding of how T. brucei evades the immune system, the researchers used a customized RNA sequencing method to catalog the distinct VSG types that appeared over time during T ...

Using a mouse model, the researchers showed that Trypanosoma brucei essentially plays a game of hide-and-seek by setting up shop in its hosts' tissues, ... the variant surface glycoprotein (VSG).