A) The structure of TLRs is characteristic of type I membrane proteins: A transmembrane domain spans the membrane (MB) and connects to an extracellular domain, which projects from the outside ...

including the natural ectodomain (ECD), the transmembrane domain (TMD), and the split TEVp intracellular domains (NTEVp or ...

Through serial passaging of LASV with inhibitors, adaptive mutants were obtained, most of which had mutations in the transmembrane (TM) domain of GP2. Characterizing the fusion inhibitor target ...