Transcription factors (TFs) are key cellular components ... The most common classification of TFs is based on the structure of their DNA-binding domains 41. Grouping TFs by structural domain ...

These TF-specific structural states may direct gene-specific regulatory events; in other words, Mediator—a general transcription factor—may acquire gene-specific functions that are triggered by TF ...

SnapShot: Mediator Complex Structure. Cell 2022, 185: 3458 ... Architecture of the human and yeast general transcription and DNA repair factor TFIIH. Mol Cell 2015, 59: 794 – 806. Allen, BL; Taatjes, ...

GET, a novel computational model, accurately predicts gene activity by analyzing chromatin accessibility and DNA sequences across diverse human cell types.

Thus, transcription-factor proteins can bind to several different ... initiation sites the group found was in root nodules, a structure on legumes' roots that harbors interaction between the ...

A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation ...

A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation ...

A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive ...

Credit: Dr. Tetsuya Muramoto The study revealed the mechanisms by which periodic intracellular cAMP signal frequencies regulate transcription factor shuttling between the nucleus and cytoplasm and ...