Nitrosylation is any chemical reaction that adds a nitrosyl group (NO). S-nitrosylation is a post-translational modification of proteins by which thiol groups (SH groups) of cysteine residues are ...

These observations clearly demonstrate that nitrite has the chemical ability to signal through heme nitrosylation– and thiol nitrosation–based mechanisms. Notably, the dose-responses produce ...

Nitrosylation and Denitrosylation The process of S-nitrosylation involves the specific reaction between thiol groups of proteins and NO, resulting in the formation of SNO. Additionally, SNO can be ...

The remaining two (Cys261 and Cys498) are free thiols and thus available for S-nitrosylation of ACE2 via a reversible nucleophilic attack on nitroso nitrogen to form SNO-protein adducts.

Learning About Memory Loss. A chemical process in the brain called S-nitrosylation - which can be activated by inflammations as well as a variety of airborne toxins - blocks brain cells from ...

More specifically, first author Takashi Uehara and coworkers have found that thiol groups at the active site of PDI are chemically modified by addition of a nitric oxide (NO) group. Because the ...

More information: Jyoti Srivastava et al, Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors, Cancer Research (2025). DOI: 10.1158/0008 ...

One of the main routes by which they may act as an anti-bacteria agent, is through attaching themselves to the thiol group present on the cellular membrane surface and hence disrupting the ...

Despite advances in processes and formulations, monoclonal antibody (mAb) processing still must identify and quantify free thiols in final products to minimize the risks of antibody aggregation ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. Sai Lomte, Tarun. (2022, July 01). The antiviral effects of thiol drugs in COVID-19.