Reversible modifications of cysteine thiols have a key role in redox signaling and regulation. A number of reversible redox modifications, including disulfide formation, S-nitrosylation (SNO ...

Nitrosylation and Denitrosylation The process of S-nitrosylation involves the specific reaction between thiol groups of proteins and NO, resulting in the formation of SNO. Additionally, SNO can be ...

The remaining two (Cys261 and Cys498) are free thiols and thus available for S-nitrosylation of ACE2 via a reversible nucleophilic attack on nitroso nitrogen to form SNO-protein adducts.

A chemical process in the brain called S-nitrosylation - which can be activated by inflammations as well as a variety of airborne toxins - blocks brain cells from making new connections ...

Despite advances in processes and formulations, monoclonal antibody (mAb) processing still must identify and quantify free thiols in final products to minimize the risks of antibody aggregation ...

More specifically, first author Takashi Uehara and coworkers have found that thiol groups at the active site of PDI are chemically modified by addition of a nitric oxide (NO) group. Because the ...