Peptide macrocycles synthesized using aziridine aldehydes are of high diastereomeric ... mixture is usually 0.2 M. In reactions in which unprotected thiols, such as cysteine or homocysteine ...

This has led to their development of highly optimized tools for one of the key methods for covalent modification of peptides and proteins: the thiol-maleimide reaction. This reaction does, however, ...

Danny Alge and Kristi Anseth contributed a chapter to a new RSC book on using thiol-based chemistry in material science. This insightful chapter highlights power applications of this exciting ...

the new approach can stitch alkyl and benzyl aldehydes with a wide range of alkynes. To demonstrate the synthetic utility of their approach, the researchers subjected reaction products to ...

This molecular robot can be programmed to stereoselectively produce, in a sequential one-pot operation, an excess of any one of four possible diastereoisomers from the addition of a thiol and an ...