202 5 年 5 月 14 日 ， 我 院天然药物及仿生药物全国重点实验 室 马明 课题组 在 Nature Chemistry 上发表了题为 “ Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon–carbon linkage ...

结核分枝杆菌转酮醇酶（mbTK）参与对细菌生存至关重要的戊糖磷酸途径，是抗结核治疗极具吸引力的靶点。研究发现了一类新的靶向 mbTK 活性位点的呋喃磺酸酯抑制剂，它们能够同时结合硫胺素二磷酸（thiamine diphosphate ）辅因子亚位点和相邻的疏水亚位点（Ile211-Leu402-Phe464），从而抑制酶活性。

A research team led by Prof. Xiaoqiang Huang from Nanjing University has developed a novel non-natural dynamic kinetic ...

Thiamine diphosphate is a necessary co-factor for several enzymes involved in the glycolytic pathway, citric acid cycle, pentose phosphate pathway, and degradation of branched chain amino acids.

Thiamine diphosphate (ThDP), Mg 2+ ions, and flavin-adenine dinucleotide (FAD) are required as cofactors to activate AHAS. Catalytic mechanism.

Beriberi in infants is a public health concern with reports in parts of Southeast Asia. Caused by thiamine (B1) deficiency, beriberi generally presents among breastfed infants at three months. A ...

The primary endpoint of the study was the level of erythrocyte (red blood cell) thiamine diphosphate (eTDP) concentrations in the women's blood, breast milk, and in the babies. Levels of eTDP of the ...