In the case of thalidomide, it was shown that one enantiomer was responsible for efficacy and another for side effects. Companies like Chiroscience (Slough, UK) and Sepracor based businesses on ...

Upon its 'reinvention', thalidomide was quickly applied to 'microenvironment-dependent' diseases such as multiple myeloma, yet its role in the solid tumor spectrum has not been validated.

"In nature and in pharmacology there are multiple examples in which the two enantiomers have different properties. A case in point is thalidomide (a drug administered as a sedative and to relieve ...