利用单细胞染色质可及性测序技术，作者们发现TFAP2C的结合motif在seminoma肿瘤细胞中显著富集，这说明TFAP2C作为转录因子参与seminoma的发生发展。 为了进一步验证，作者们在seminoma细胞系中敲降了 TFAP2C 的表达，发现敲降后大量基因出现下调，且肿瘤细胞的迁移和侵袭能力显著降低。

该研究探讨了这些异常表达的基因在seminoma肿瘤细胞中的作用。 睾丸生殖细胞瘤（Testicular germ cell tumors，TGCTs）是14-44岁男性中最常见的恶性实体瘤 ...

The optimum management of patients with low-stage seminoma remains a matter of debate. Here, Resnick et al. detail the case of a 51-year-old man who was diagnosed with bilateral stage I testicular ...

Diagnosis Bilateral metachronous testicular seminoma, stage pT1N0M0S0. Management Radiotherapy, radical orchiectomy, bilateral placement of testicular prostheses, androgen substitution therapy ...

Patients with clinical stage I seminoma diagnosed from January 2013 to December 2018 were identified in the prospective Danish Testicular Cancer database. By linkage to the Danish National Pathology ...

Survivors of metastatic testicular seminoma can suffer long-term toxicities from radiotherapy or systemic chemotherapy. This prospective phase II study examined whether retroperitoneal lymph node ...

Retroperitoneal lymph node dissection (RPLND) could become a first-line option in testicular seminoma, as it has lower toxicity than standard care.

Seminoma was identified in 11 patients (testicular in 8 and extratesticular in 3). The paraneoplastic neurologic syndrome led to testing that revealed the diagnosis of the tumor in 8 of the 11 ...

Non-seminoma is a type of germ-cell testicular cancer. Learn more about its symptoms, risk factors, treatment options, and outlook here.

Testicular seminoma has a predictable pattern of metastatic spread, making it one of the very few curable metastatic cancers. The normal template of dissection is basically from the kidney vessels ...

Cite this: EAU 2009: New Marker May Predict Clinical Course of Testicular Seminoma - Medscape - Mar 27, 2009. Authors and Disclosures. Authors and Disclosures Journalist Fran Lowry.

Patients with stage IIa testicular seminoma experienced prolonged OS when they received radiotherapy rather than multi-agent chemotherapy, according to an analysis using the National Cancer Data ...