Mutations in telomerase and telomere gene components manifest as diverse clinical syndromes that vary in severity but share a single common molecular defect of shortened telomeres. Telomere length ...

Telomere crisis, which occurs during tumorigenesis when short telomeres become dysfunctional, is hypothesized to be a major source of the instability observed in cancer genomes (Figure 1). Telomere ...

The ends of linear eukaryotic chromosomes are protected by telomeres, which serve to ensure proper chromosome replication and to prevent spurious recombination at chromosome ends. In this study ...

Telomeres are specialized nucleoprotein structures at the ends of eukaryotic chromosomes that are essential for chromosome stability and cellular proliferation. Telomeric DNA does not encode for ...

It's all about the little caps on our chromosomes called telomeres. They work like the plastic tips of shoelaces to protect the ends of chromosomes, the strings of genes in the heart of every cell ...

A major goal of the Sfeir is to understand the mechanism(s) underlying telomere length regulation, which is critical for cellular survival. We are particularly interested in uncovering the pathway(s) ...

While many attribute this to genetics, lifestyle, or even sheer luck, science is increasingly turning its focus to telomeres, which are protective caps at the end of DNA. Telomeres are structures ...

Longer leukocyte telomeres are linked to a lower risk for stroke, dementia, and late-life depression (LLD), early research suggests. The findings also indicated that adopting a healthy lifestyle ...