She spoke to Adam Levy about her pioneering work on the structure and function of telomerase, and its vital role in everyday cell function and disease. Nguyen describes how revelations about its ...

We develop this knowledge by first understanding the core activities of key telomere factors, then testing these activities in a reconstituted telomerase assay and validating our knowledge directly in ...

Due to this phenomenon, scientists describe telomere length as a biological clock that indicates the lifespan of a cell and an organism. Telomerase is a ribonucleoprotein enzyme responsible for ...

They found that the phenotype of the telomerase null offspring was similar to that of the late generation parent, although only half of the chromosomes were short. In addition, spectral karyotyping ...

Their work has revealed how organisms rely on the enzyme to protect their genome from degradation, and laid the groundwork for later studies linking telomerase to cancer and aging-related ailments in ...

The findings provide new insight into how human telomeres function at the molecular level, with implications for numerous diseases and disorders. "After the discovery of telomerase, it took ...