Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is ...

Figure 1: The products of two genes are required to reconstitute basic telomerase activity; the RNA component, hTR, which includes the template for synthesis of telomere DNA, and the protein ...

Telomeres are important to human health because dysregulation of either telomere protection or telomerase activity causes many human diseases. Notably, over 90% of human cancers activate telomerase ...

Researchers have developed HuT mice, a genetically engineered model with human-like telomeres, enabling scientists to study ...

Edited by: Karen Young Kreeger C.M. Counter, J. Gupta, C.B. Harley, B. Leber, S. Bacchetti, "Telomerase activity in normal leukocytes and hematologic malignancies ...

New research indicates that a natural compound found in the skin of grapes, blueberries and raspberries has the potential to ...

de Lange is also thinking about how this process could be involved in cancer. Cancer cells’ genomes are plagued by DNA breaks, but their survival and proliferation depends on them finding a way to ...

In Szostak’s lab, further work with yeast demonstrated just how vital telomerase activity is for cells. Szostak and postdoctoral fellow Victoria Lundblad identified genetic mutants of yeast that were ...

The majority of human cancer cells express high levels of telomerase and inhibition of telomerase activity kills the cancer cells without effect on most normal somatic cells. Dr. Tollefsbol’s ...

A new study has highlighted the potential of resveratrol, a natural compound found in grapes, blueberries, and raspberries, to enhance female fertility. The systematic review found that resveratrol ...

Geron Corporation (Nasdaq: GERN), a commercial stage biopharmaceutical company, today reported that it has granted equity awards covering an aggregate ...