Andy Tao, Purdue professor of biochemistry and the senior author of the findings published in the journal ACS Central Science. “It’s important to know all the alternative kinases that can ...

One of the most important classes of human enzymes are protein kinases - signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism.

One of the most important classes of human enzymes are protein kinases -- signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism.

“Certain MAP kinases are frequently hyperactivated in cancer and they have become drug targets for treatment,” Turk explained. “Understanding how and where kinases act will help us understand their ...

You block one pathway, and they find another." The kinase-protein maps Tao is creating identify kinases and the direct protein targets they phosphorylate. His method weeds out other proteins that ...

"Kinases and their substrates are pivotal in cellular signaling pathways, and the ability to visualize these interactions in system-level contexts opens new avenues for understanding their roles ...

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

While understanding the components and molecular mechanisms behind these signaling strategies is important, the exact involvement of individual kinases and substrates has not been clearly elucidated.

CAMBRIDGE -- One of the most important classes of human enzymes are protein kinases — signaling molecules that regulate nearly all cellular activities, including growth, cell division ...