Capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide), a component of red chili peppers, is an agonist of transient receptor potential vanilloid type1 (TRPV1) whose activation increases pain by ...

TRPV1最初是作为辣椒素（capsaicin）受体被发现的，因此也被称为辣椒素受体或香草素受体1，其发现者David Julius教授凭借在发现感知温度受体上的突出 ...

The capsaicin receptor, the transient receptor potential vanilloid 1 (TRPV1) cation channel has been detected in skeletal muscle, the role of which remains unclear. Here we report the function of ...

本研究针对白内障术后后囊膜混浊（PCO）这一常见并发症，探究了TRPV1通道通过钙蛋白酶（Calpain）-蛋白酪氨酸磷酸酶（PTP）通路抑制晶状体上皮细胞上皮-间质转化（EMT）的分子机制。研究人员通过体外和离体实验证实，TRPV1激动剂辣椒素（Capsaicin）通过激活 ...

Takayama and Tominaga in National Institute for Physiological Sciences (NIPS) (Okazaki Institute for Integrative Bioscience) clarified that an interaction between capsaicin receptor TRPV1 and ...

Researchers have clarified that an interaction between capsaicin receptor TRPV1 and chloride channel anoctamin 1 causes enhancement of the capsaicin-evoked pain sensation in mice. Drs. Takayama ...

Takayama and Tominaga in National Institute for Physiological Sciences (NIPS) (Okazaki Institute for Integrative Bioscience) clarified that an interaction between capsaicin receptor TRPV1 and ...

Spicy food may support a healthier microbiome, too. Though data are limited, “spicy foods appear to increase the microbiome’s ...

His team identified the receptor responsive to capsaicin, TRPV1, and showed that it is also activated by heat and inflammatory chemicals. More recently, he has revealed how scorpion venom targets ...

Med. Chem. 2018, DOI: 10.1021/acs.jmedchem.8b00109). Capsaicin soothes pain and itch by propping open an ion channel called TRPV1 in cells. But not surprisingly, given its spicy reputation ...

Capsaicin, which doesn’t have any calories or nutrients, binds to TRPV1, a channel of nerves that detects internal or external sources of heat. Exposure to heat sources such as capsaicin makes ...