Tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, has been implicated in the pathogenesis of AD. Objective: To investigate the use of a biologic TNF-alpha inhibitor, etanercept was ...

However, since TNF is a cytokine with pleiotropic effects, interfering with many immunological functions and pathways, the precise mechanisms by which these agents reduce inflammation in these ...

This function may be exploited for microRNA-mediated ... (A+U)-rich elements in the 3′ untranslated region (UTR) of the TNF alpha mRNA. Now the researchers introduce a miRNA as the mediator ...

today announced that it has achieved a key safety data milestone supporting expanded and longer-term clinical studies of its novel TNF-alpha (TNF-α) inhibitor drug, isomyosamine, in multiple ...