为探究成年心脏成纤维细胞中细胞自主免疫信号如何调控纤维化，来自印度 Amrita Vishwa Vidyapeetham 的研究人员开展了关于 TLR4 信号在心脏成纤维细胞中作用的研究。结果表明，抑制 TLR4 信号可调节体外纤维化变化。这为治疗心脏损伤后的纤维化提供了新方向。

We evaluated ROS level and the mechanism associated with ROS generation after TLR4 signaling and GC cell proliferation. Oxidase inhibitors and antioxidants were used to explain the source of TLR4 ...

Investigating TLR4 expression in benign and malignant ovarian tumors in situ and its signaling in human OvCa cell lines, we show that TLR4 has a significant function in growth of ovarian tumor ...

Further analysis identified a molecular signaling pathway underlying the inhibitory effects of TLR4 triggering on CD4+ T cell inflammatory function, providing insight into the regulation of CD4+ T ...

Specifically, these mice have low levels of free iron in immune cells known as macrophages and this impairs signaling along a ... an inflammatory response (the TLR4/TRAM/TRIF pathway).

Gum disease caused by the bacteria Porphyromonas gingivalis is linked to worse multiple sclerosis (MS) in a mouse model of ...