Investigating TLR4 expression in benign and malignant ovarian tumors in situ and its signaling in human OvCa cell lines, we show that TLR4 has a significant function in growth of ovarian tumor ...

We evaluated ROS level and the mechanism associated with ROS generation after TLR4 signaling and GC cell proliferation. Oxidase inhibitors and antioxidants were used to explain the source of TLR4 ...

Gum disease caused by the bacteria Porphyromonas gingivalis is linked to worse multiple sclerosis (MS) in a mouse model of ...

Further analysis identified a molecular signaling pathway underlying the inhibitory effects of TLR4 triggering on CD4+ T cell inflammatory function, providing insight into the regulation of CD4+ T ...

Specifically, these mice have low levels of free iron in immune cells known as macrophages and this impairs signaling along a ... an inflammatory response (the TLR4/TRAM/TRIF pathway).