Dr. Massagué, who is Director of the Sloan Kettering Institute as well as MSK’s Chief Scientific Officer, is known for his pioneering work that uncovered the mechanism of action for transforming ...

For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work ...

Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of ...

Decreased TGF-beta Signaling Might Make You Demented Date: November 3, 2006 Source: Journal of Clinical Investigation Summary: The physical changes that occur in the brain of patients with ...

This study showed that TGF-ß signaling in P. pacificus is important for forming the mouth structures associated with predation and notably, also for establishing the kin signal to identify and protect ...

For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once ...

LDS-associated mutations are predicted to reduce TGF-β signaling; however, aortic tissue samples from LDS patients indicate that TGF-β signaling may be enhanced.

Normally, TGF-Beta soothes the immune system, and some cancers use it to evade attack. It also triggers a signaling cascade within cells to repair their DNA. Barcellos-Hoff wondered if certain tumors ...

Clinical and Research Institute on Addictions 1021 Main Street, Buffalo, NY 14203-1016. Phone: (716) 887-2566 Email: [email protected] ...

On its own, TGF-beta — a type of signaling protein known as a cytokine — is not an ideal drug target. That’s because it plays a variety of important roles throughout the body, ...

A tale of two signaling pathways: TGF-Beta and RAS. On its own, TGF-beta—a type of signaling protein known as a cytokine—is not an ideal drug target.

Why context is key for TGF-Beta's role in cancer metastasis. The study brings together two longstanding areas of research for the Massagué Lab: TGF-beta signaling and metastasis.