More information: Mingliang Jin et al, Dynamic allostery drives autocrine and paracrine TGF-β signaling, Cell (2024). DOI: 10.1016/j.cell.2024.08.036 Provided by University of California, San ...

Transforming growth factor-beta (TGF-β), a well-known morphogen ... of Sciences revealed the molecular mechanism of TGF-β ...

TGF-Beta is a pleiotropic cytokine expressed by almost every tissue and cell type, is stored in abundance in the extracellular matrix, and possesses suppressive and stimulatory signaling pathways.