The best understood species is Caenorhabditis elegans and one of the many questions scientists investigate in this model species is “cellular signaling”, the way how molecules work together to control ...

Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of ...

Dr. Massagué, who is Director of the Sloan Kettering Institute as well as MSK’s Chief Scientific Officer, is known for his pioneering work that uncovered the mechanism of action for transforming ...

On its own, TGF-beta — a type of signaling protein known as a cytokine — is not an ideal drug target. That’s because it plays a variety of important roles throughout the body, ...

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So they generated mice in which signaling by the molecule that triggers T-beta-RII, TGF-beta, is decreased. Analysis of these mice showed age-dependent neurodegeneration and beta-amyloid peptide ...

More information: Mingliang Jin et al, Dynamic allostery drives autocrine and paracrine TGF-β signaling, Cell (2024). DOI: 10.1016/j.cell.2024.08.036 Provided by University of California, San ...

Dual functionality But TGF-β signaling in cancer is complex, exerting context-dependent effects, as Heldin explains: “On one hand, it’s suppressing tumor formation, and on the other, it can also ...

That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS signaling pathways work together to spur the spread of ...

A tale of two signaling pathways: TGF-Beta and RAS. On its own, TGF-beta—a type of signaling protein known as a cytokine—is not an ideal drug target.

For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once ...