Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases.

Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling has fundamental roles in both embryonic skeletal development and postnatal bone homeostasis. TGF-βs and BMPs ...

The most important molecular counterpart is the bone morphogenetic protein (BMP)-7, also belonging to the TGF-β superfamily. BMP-7 not only inhibits EMT, but can even induce a mesenchymal ...

Whereas several TGF-β and BMP ligands had similar effects on the proliferation of FOP- and resFOP-iMSCs, BMP-9 specifically enhanced the growth of FOP-iMSCs, an observation further confirmed ...

Staining intensity for BMP-12, bFGF, TGF-beta and VEGF showed all were highly expressed at early healing stages, so the researchers introduced BMP-12, cDNA and TGF-beta cDNA — as well as an ...

LEXINGTON, Mass., Sept. 03, 2024 (GLOBE NEWSWIRE) -- Keros Therapeutics, Inc. (“Keros” or the “Company”) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing ...

BMP-7 or BMP-7 peptide fragments antagonize TGF-β, antifibrotic effect, stimulation of liver regeneration TGF-β/BMP-7 Ratio Determines epithelial-mesenchymal transition (EMT) and profibrogenic ...