CD3 (including its subunits CD3ε, CD3δ, CD3γ, and CD3ζ) is the central component of the TCR-CD3 complex and is crucial for recognizing T cells and responding to antigens. Every subunit of CD3 ...

The initial signal is made up of a combination of TCR/CD3 and antigen-presenting cell (APCs) surface-specific MHC molecule antigen-peptide complexes. The next signal is a non-specific co ...

Kapetanovic was able to decouple the desired from the undesired activation by creating a synthetic TCR-CD3 complex. Killer T cells with this synthetic complex are no longer able to respond to ...

Partnership leverages Medigene’s leadership for T cell receptor (TCR) generation and characterization and WuXi Biologics’ unique anti-CD3 mAb, its T cell engager (TCE) platform and proprietary ...

11,12 (8) Synthetic TCR antigen receptor/HLA-independent TCR (STAR/HIT) constructs retain the full complex of CD3 signaling but also have high antigen sensitivity via the fusion of an antibody binding ...

The multi-target collaboration combines the respective expertise of each company with Medigene’s 3S (sensitive, specific and safe) TCR generation and characterization capabilities and EpimAb’s ...

(8) Synthetic TCR antigen receptor/HLA-independent TCR (STAR/HIT) constructs retain the full complex of CD3 signaling but also have high antigen sensitivity via the fusion of an antibody binding ...

These optimal 3S TCRs can subsequently be merged with a Cluster of Differentiation 3 (CD3) T cell engaging antibody. The TCR-TCEs specifically redirect the patient’s own T cells towards the ...

Partnership leverages Medigene's leadership for T cell receptor (TCR) generation and characterization and WuXi Biologics' unique anti-CD3 mAb, its T cell engager (TCE) platform and proprietary ...

Kapetanovic was able to decouple the desired from the undesired activation by creating a synthetic TCR-CD3 complex. Killer T cells with this synthetic complex are no longer able to respond to foreign ...