It is now known that Lck is the most proximal kinase involved in TCR signaling, brought in T cells into close proximity with its substrates, the tyrosines in the ITAMs of the TCR, by the ...

In atopic dermatitis, psoriasis and other dermatologic diseases, T cells lose tolerance to self-antigens, triggering the autoimmune response that leads to abnormal skin cell proliferation and ...

Rawlings and his team found that both cell lines had increased TCR signaling when stimulated, similar to observations from previous mouse studies. To their knockout cell population, the researchers ...

Triumvira Immunologics, a clinical-stage company developing novel, targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors ...