癌症会耗尽机体内的T细胞，这是因为敌对的肿瘤微环境会消耗T细胞中的线粒体活性，导致T细胞耗竭，进而阻碍了过继细胞疗法（Adoptive Cell Transfer ...

Nevertheless, Anixa hopes to develop the first approved CAR T-cell therapy for a solid tumor indication. The company has identified a protein called the follicle-stimulating hormone receptor (FSHR ...

Liu concluded, “As our XOFLX system only uses one transfer plasmid or no plasmid at all for LVV production, ... a CD20/CD19-targeting CAR T-cell therapy to treat B-cell malignancies, ...

On February 13, Allogene Therapeutics published new long-term follow-up data on cemacabtagene ansegedleucel, showing the investigative allogeneic chimeric antigen receptor (CAR) T-cell therapy ...

CAR-T cell therapy, which involves genetically engineered T-lymphocytes targeting cancer cells, has shown high efficacy in blood cancers and is being explored for solid tumors and autoimmune diseases.

CAR T-cell therapy has significantly improved outcomes for B-ALL patients, but relapse still occurs in over 50% of cases, leaving many with limited treatment options.

Cellular Origins has entered into a collaboration with Johnson & Johnson to develop a scalable, end-to-end automated platform ...

Cordas dos Santos DM, Tix T, Shouval R, et al. A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy. Nature Med. July 8, 2024. DOI 10.1038/s41591-024-03084-6.

Researchers found that, upon CAR T-cell therapy, microglia – the brain’s immune cells – produces chemicals like cytokines and chemokines as part of its inflammatory response.

In modern immunotherapy, modified immune cells are introduced into the body to attack tumors and other targets. Researchers at the Technical University of Munich (TUM) have developed a method for ...

Local immune effector cell–associated toxicity syndrome is a newly identified side effect observed in many patients receiving CD19-targeting CAR T-cell therapy for autoimmune conditions.

CAR-T cell therapy for hematologic cancers is now available at St. George Regional Hospital. Jacqueline, a Las Vegas patient who traveled to Salt Lake City for the treatment, said it saved her life.