sought to engineer cells to counter immune over-activation ... up pro-inflammatory IL-2. The authors demonstrated the in vivo potential of the CD19-activated suppressor T cells to protect against ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

is a novel CD8+ T cell selective IL-2, generated by fusing a reduced potency IL-2 mutein to an anti-CD8β antibody. It was specifically engineered to selectively and potently activate CD8+ T-cells ...