More information: Yu Hou et al, Neuropeptide signalling orchestrates T cell differentiation, Nature (2024). DOI: 10.1038/s41586-024-08049-w Provided by Brigham and Women’s Hospital ...

However, the multiple cell types within a tissue don't just have different functions. They also have different transcriptional programs and may well divide at different rates. Proper regulation of ...

However, scientists haven't fully understood whether infected tissue itself has any role in directing the optimal T cell differentiation in response to tissue infection.

Philip M and Schietinger A. CD8 T cell differentiation and dysfunction in cancer. Nature Reviews Immunology. 2022 Apr;22(4):209-223. TOX is a critical regulator of tumour-specific T cell ...

Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

VectorBuilder's partner, Ucello, announced that its CD19-targeting umbilical cord blood-derived allogeneic CAR-T cell therapy ...

Scientists from our program have played a central role in the development of several types of immunotherapy that are currently transforming cancer care, including checkpoint blockade and CAR T cell ...