These agents comprise several different classes of antifungal medications, with differing mechanisms of action, antifungal spectrum of activity, pharmacokinetics and clinical uses in pediatrics ...

Invasive fungal infections are a major medical concern, particularly in immunocompromised patients. In this Review, Perfect discusses the antifungal pipeline, including advances in the currently ...

Antifungal medications treat fungal infections by attacking aspects unique to the fungal cells. ... Flucytosine can be used to treat systemic infections with Candida or Cryptococcus species.

However, systemic antifungals began to be used with the development of amphotericin B-deoxycholate by Squibb Laboratories in 1958. ... By enhancing the toxicity of the other drug: ...

All the latest science news on antifungal drugs from Phys.org. Find the latest news, advancements, and breakthroughs. Topics. ... Systemic fungal infections are much rarer than other illnesses, ...

A, Trends in antifungal therapy for disseminated systemic candidiasis. B, Trends in antifungal therapy for aspergillosis. Trends in antifungal therapy for neonatal hospitalizations, 2000-2006.

That makes them less appealing than drugs taken continuously, such as statins. Despite these hurdles, wholly new classes of antifungals are finally on the cusp of reaching the clinic.

A standard treatment protocol for FE is not yet established. Initiation with a broad-spectrum systemic antifungal drug with or without an intravitreal antifungal drug is recommended. Systemic ...