By analyzing the effects genetic variants had on brain cells, they found the cause of a new rare condition—glutamine synthetase stabilization disorder—which causes seizures and delayed ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

No safety concerns identified by independent data and safety monitoring board (DSMB), which recommends continuation of study ...

Functional assays included fluorescence measurements for muGFP and high-throughput amide synthetase activity screening. Reactions were conducted in 384-well plates, incubated at 37 °C ...