Ultrafast endocytosis can retrieve a single, large endocytic vesicle as fast as 50–100 ms after synaptic vesicle fusion. However, the fate of the large endocytic vesicles is not known.

The function of synaptic vesicles is to store neurotransmitters and to release them into the synaptic cleft in response to elevated intracellular calcium. To do this, they contain transmitter ...

How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, ...

Researchers have developed a groundbreaking computational model that provides detailed insights into the vesicle cycle, a key ...

Synaptic vesicles are tiny, membrane-enclosed compartments that package and release messenger compounds, such as neurotransmitters, in neurons. Researchers have identified common proteins ...

In A, researchers used a fluorescent protein (synaptopHluorin) to visualize synaptic vesicle movement. Some vesicles stay open briefly before retrieval (kiss-and-run). Others stay open longer but also ...

Imaging synaptic vesicles in 3D Date: December 3, 2024 Source: Max Delbrück Center for Molecular Medicine in the Helmholtz Association Summary: Researchers have used cryo-electron tomography to ...

These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, researchers have successfully modeled ...

Using cryo-electron tomography, the team was able to visualize synaptic vesicles (SVs) in 3D and confirm a potentially important protein-protein interaction. They also broadened our understanding ...

They also broadened our understanding of SV function and of how the vesicles are recycled. The study was published in the Proceedings of the National Academy of Sciences (PNAS.) “Synaptic ...

Writing in the September 25 Current Biology, researchers led by Subhojit Roy at the University of California, San Diego, report that the protein multimers latch onto synaptic vesicles, herding them ...

Researchers at the Max Delbrück Center have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain.