First discovered as proteins found on synaptic vesicles and at the presynaptic plasma membrane, SNAREs are members of a family of highly conserved proteins that reside on vesicles (v-SNAREs ...

The study introduces new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. This ...

It reveals a pore complex with extended arms that could bind receptors involved in synaptic vesicle exocytosis. Perhaps these multiple actions are needed to cover the diversity of targets ...

A recent study published in Psychophysiology provides new insights into how stimulating the vagus nerve through the ear might ...

Clathrin-mediated endocytosis (CME) plays a crucial role in synaptic vesicle trafficking, and it has been hypothesized that CME impairment contributes to neuropathology related to schizophrenia.

A GROUNDBREAKING study has identified rare genetic variants in the ITSN1 gene that increase Parkinson’s disease risk by up to tenfold and reveal unexpected links to autism spectrum disorder (ASD), ...

Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ... the presynaptic neuron and restored inside a vesicle ready to be used again.