This Case Study describes a novel KCNJ11 mutation, His46Leu, causing iDEND syndrome. Sulfonylurea (glibenclamide) therapy not only restored glucose homeostasis, but also alleviated some of the ...

Glycated hemoglobin levels improved in all patients who switched to sulfonylurea therapy (from 8.1 percent before treatment to 6.4 percent after 12 weeks of treatment, P<0.001). Improved glycemic ...

In contrast, sulfonylurea and insulin were often used as second- or third-line medications, and only 2,879 (48.2%) among 5,970 ever users of sulfonylurea had it as their only first diabetes therapy.

Demographic data included age, sex, health insurance (private/statutory health insurance), and practice region (East/West Germany). Obesity diagnosis, lipid disorders, hypertension, use of ...

The purpose of this study was to determine if the risk of death changes with level of exposure to sulfonylurea drugs. Methods: This was a retrospective, inception cohort study using administrative ...

In the sulfonylurea–insulin group, relative reductions in risk persisted at 10 years for any diabetes-related end point (9%, P=0.04) and microvascular disease (24%, P=0.001), and risk reductions ...

Analysis included 898 patients (41.0 percent insulin users; 65.1 percent sulfonylurea users). The researchers found that overall, IAH prevalence was 41.0 percent using the Gold questionnaire and ...

Long Wong, from Guangdong General Hospital in Guangzhou, China, and colleagues examined the effect of sulfonylurea-based oral antidiabetic agents on testosterone levels.Data were collected for 15 ...

Participants were treated with insulin or sulfonylurea between August and November 2022. Researchers assessed the participants' degree of impaired awareness of their hypoglycemia status ...

Your doctor will probably want to check your blood sugar and urine sugar levels often while you’re taking a sulfonylurea. Keep all appointments with your doctors and all required tests.

Evidence is inconsistent for the association between sulfonylurea use and risk of cardiovascular disease among patients with diabetes. We aimed to prospectively evaluate this association using the ...