P1 and PAC clones specific for all human subtelomeric chromosome regions 17. We describe here the development of a 12-color FISH assay for telomeric rearrangements (termed M-TEL) using an updated ...

2 "Using shotgun cloning, most of the human genome has been sequenced. However, this approach has missed most of the regions near telomeres, because repetitive sequences do not clone well. The ...

These deletions would have been missed or incorrectly characterized by subtelomeric FISH panels that use a single clone to the most distal unique sequence for each region. In addition, six (3.5% ...