The substantia nigra is a motor nucleus located in the basal ganglia of the midbrain. This brain structure contributes to the body's cognitive and motor functions by sending signals to initiate or ...

Rather, the major 'novelty center' of the brain -- called the substantia nigra/ventral tegmental area (SN/VTA) -- might be activated by the unexpectedness of a stimulus, the emotional arousal it ...

They lack the loss of dopaminergic neurons in the substantia nigra, however—a hallmark of PD— although they undergo a progressive loss of these cells’ terminals. Many of the behavioral and ...

Parkinson’s disease is a neurodegenerative disorder characterized by loss of dopamine neurons in the substantia nigra and widespread accumulation of misfolded α-synuclein and Lewy bodies in the ...

For the first time, researchers have sorted large numbers of human brain cells in the substantia nigra into 10 distinct types. Just one is especially vulnerable in Parkinson’s disease ...

In a recent study published in Progress in Neurobiology, researchers discover that the substantia nigra of individuals with Parkinson’s disease had a higher concentration of pheomelanin ...

About The Study: In this cross-sectional study of contact sports athletes with chronic traumatic encephalopathy (CTE), years of contact sports participation were associated with substantia nigra ...