撰文丨王聪编辑丨王多鱼排版丨水成文干扰素基因刺激因子（STING）通路在启动针对病原体和肿瘤的免疫反应中发挥着关键作用。STING 信号的激活对于多种癌症疗法的抗肿瘤效果至关重要，STING 激动剂在小鼠模型中治疗不同癌症方面展现出了令人瞩目的潜力。然而，STING ...

▎药明康德内容团队编辑（来源：复旦大学）近日，复旦大学附属华山医院刘杰教授、骆菲菲研究员团队在《肿瘤细胞》（Cancer Cell）发表题为“Targeting tumor monocyte-intrinsic PD-L1 by rewiring ...

Pfizer has terminated a Phase I trial of its investigational STING therapy in advanced solid tumors, according to an update ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

That STING activity summons killer T cells in the immune system to attack the cancer. In the study, the researchers observed the appearance of killer T cells that recognize and kill KRAS ...

Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as ...

Researchers Uncover Key Missing Link in Understanding Autoimmune DisordersAutoimmune diseases, which are estimated to affect ...

A research led by Sergio P. Acebrón, Researcher Ikerbasque at the UPV/EHU, develops a key tool to visualize the immune response to abnormal DNA, opening new avenues for the treatment of diseases.

Another of STING's main functions is regulating the acidity within the Golgi apparatus, a structure within cells that processes, packages, and transports proteins and lipids in the body.