Sterols, such as cholesterol in our bodies ... yet are synthesized through notoriously long, complex metabolic pathways. Researchers from UC San Diego and the NIH have used a novel combination ...

Already, the researchers are publishing follow-up scholarship and discovery based on their new breakthrough in understanding the sterol synthesis pathway in the parasites. They said drugmakers and ...

This specific sterol plays a key role in the synthesis of cell membranes ... highly regulated via the relevant biochemical signaling pathways. Following this, another enzyme called mevalonate ...

They also studied what would happen if they mutated genes for enzymes "upstream" from this particular enzyme in the multi-step sterol synthesis pathway. And they measured sterol levels in these ...

They also studied what would happen if they mutated genes for enzymes “upstream” from this particular enzyme in the multi-step sterol synthesis pathway. And they measured sterol levels in ...

"This inhibition raises the levels of 7-dehydrocholesterol (7-DHC), suppresses cholesterol synthesis, and generates a sterol profile indistinguishable from that seen in congenital metabolic ...