This protein is involved in various physiological ... In the work reported here, we demonstrated that STAG1 was strongly induced by p53-121F, and that enforced expression of STAG1 using a ...

What is particularly remarkable about this discovery is that these disturbances cannot be compensated for by the STAG1 protein, highlighting the role of STAG2 in AML. In a further step ...

Zhang and colleagues have now shown that ARID1A is essential for telomere cohesion as it controls expression of STAG1, a component of the cohesin protein complex. In fact, ablation of ARID1A ...

Cohesin is a ring-shaped protein that surrounds and moves around ... In vertebrate cells, there are two versions of cohesin, known as STAG1 cohesin and STAG2 cohesin, although it is not known ...

"Actually, cohesin is a protein complex made of multiple subunits," Losada explains. "Cells have two versions of this complex; one of them carries the STAG1 subunit, and the other, the STAG2 subunit.

That gene and related genes called STAG1 and STAG3 code for subunits of ... resistant to inhibition of both BRAF and of MEK, another protein in the MAPK pathway. They identified what may be ...

Zhang and colleagues have now shown that ARID1A is essential for telomere cohesion as it controls expression of STAG1, a component of the cohesin protein complex. In fact, ablation of ARID1A ...