A new class of non-opioid drugs treats pain by blocking signals before they reach the brain, reducing the risk of addiction.

Inflammation in the brain and spinal cord has been shown to promote chronic pain. This is thought to be because inflammation sensitizes the nervous system to experience high levels of pain, even when ...

Infectious or chronic diseases such as long COVID, Alzheimer’s disease and traumatic brain injury can cause inflammation in ...

Meningitis is caused by germs that can do just that-- an infection that attacks the lining around the brain and spinal cord ... seen in a number of ways. The inflammation produces a fever or ...

Ankylosing spondylitis is a type of arthritis that causes pain and stiffness in your spine. It usually starts ... "Spondylitis" means inflammation of the vertebra. There is no cure for AS.

Figure 1: Regulatory checkpoints of peripheral pain hypersensitivity and of systemic inflammation ... to its specific localization to the blood-brain barrier.

Smoking has long been associated with various health risks, such as lung disease, but its detrimental effects on the spine ... brain processes sensory stimuli and the central perception of pain ...

although the causes of altered pain processing in the brain and spinal cord remain elusive. “The reasons for this dysregulation at this point can only be speculated because no specific ...

Chronic pain is widespread in the United States, particularly among military veterans, affecting between 40 to 70% of this population and serving as a ...