The targeting of transport vesicles to the correct membrane destination involves a much larger set of proteins than anticipated and several layers of protein–protein interactions. The process of ...

There is very little about membrane vesicle fusion that Yale University biochemist James Rothman doesn’t know—he codiscovered SNAREs, the proteins that orchestrate the process. But one unanswered ...

Figure 1 | Subcellular localization of mammalian SNAREs. The mammalian SNAREs that have been studied so far localize to distinct subcellular compartments in the secretory pathway. (Red, syntaxin ...