The molecular interaction between smooth muscle (SM) myosin and actin in the corpus cavernosum (CC) determines the erectile state of the penis. A key mechanism regulating this interaction and ...

There are two possible conformations of myosin in complex with Mg–ADP–BeF 3, a transition-state (ADP-Pi) analog (Fig. 1b).Based on the crystal structure of smooth muscle myosin 2, which has a ...

When myosin pulls actin filaments together, the sarcomere length is reduced. In non-muscle and smooth muscle cells, actomyosin is not organized into sarcomeres.

Smooth muscle cells can be activated by neuronal signaling or by hormones. Both mechanisms lead to a change in calcium levels in the muscle cells. This leads to activation of myosin, and, in turn ...

A mutation in the myosin heavy chain 11 gene has been found to be responsible for a syndrome associated with aortic aneurysm/dissection and patent ductus arteriosus referred to as TADD.