The molecular interaction between smooth muscle (SM) myosin and actin in the corpus cavernosum (CC) determines the erectile state of the penis. A key mechanism regulating this interaction and ...

Smooth muscle cells can be activated by neuronal signaling or by hormones. Both mechanisms lead to a change in calcium levels in the muscle cells. This leads to activation of myosin, and, in turn ...

We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our ...

When myosin pulls actin filaments together, the sarcomere length is reduced. In non-muscle and smooth muscle cells, actomyosin is not organized into sarcomeres.

This achievement could aid in the hunt for new ways to treat diseases associated with myosin malfunction. ... Single-molecule imaging reveals how myosin moves to bring about muscle contraction.