The molecular interaction between smooth muscle (SM) myosin and actin in the corpus cavernosum (CC) determines the erectile state of the penis. A key mechanism regulating this interaction and ...

When myosin pulls actin filaments together, the sarcomere length is reduced. In non-muscle and smooth muscle cells, actomyosin is not organized into sarcomeres.

Smooth muscle cells can be activated by neuronal signaling or by hormones. Both mechanisms lead to a change in calcium levels in the muscle cells. This leads to activation of myosin, and, in turn ...

This achievement could aid in the hunt for new ways to treat diseases associated with myosin malfunction. ... Single-molecule imaging reveals how myosin moves to bring about muscle contraction.

At the molecular level, muscle contraction is defined by myosin molecules pulling actin filaments. New electron cryomicroscopy images with unprecedented resolution taken by researchers at Osaka ...

A mutation in the myosin heavy chain 11 gene has been found to be responsible for a syndrome associated with aortic aneurysm/dissection and patent ductus arteriosus referred to as TADD.

Cytokinetics Inc. has disclosed fast skeletal muscle myosin inhibitors reported to be useful for the treatment of Becker muscular dystrophy, Duchenne muscular dystrophy, facioscapulohumeral muscular ...