The molecular interaction between smooth muscle (SM) myosin and actin in the corpus cavernosum (CC) determines the erectile state of the penis. A key mechanism regulating this interaction and ...

There are two possible conformations of myosin in complex with Mg–ADP–BeF 3, a transition-state (ADP-Pi) analog (Fig. 1b).Based on the crystal structure of smooth muscle myosin 2, which has a ...

Smooth muscle cells can be activated by neuronal signaling or by hormones. Both mechanisms lead to a change in calcium levels in the muscle cells. This leads to activation of myosin, and, in turn ...

When myosin pulls actin filaments together, the sarcomere length is reduced. In non-muscle and smooth muscle cells, actomyosin is not organized into sarcomeres.

A mutation in the myosin heavy chain 11 gene has been found to be responsible for a syndrome associated with aortic aneurysm/dissection and patent ductus arteriosus referred to as TADD.