The motivation behind seeking an answer to the question “Is RNAi of target X likely to induce the same phenotype as a small-molecule inhibitor of target X?” is two-fold. First, in a target ...

In the search for anticancer drugs, a promising area involves the design of small-molecule inhibitors of growth factors active in malignancies. PDGF and its receptors are implicated in ...

A retrospective case series found that treatment with an interleukin (IL)-5 inhibitor reduced eosinophil levels and improved clinical outcomes in patients with drug reaction with eosinophilia and ...