The motivation behind seeking an answer to the question “Is RNAi of target X likely to induce the same phenotype as a small-molecule inhibitor of target X?” is two-fold. First, in a target ...

CalciMedica’s lead candidate, Auxora, is a small-molecule inhibitor of Orai1 that both ... Auxora reduced expression of a variety of interleukins, as well as interferon-gamma (IFN-γ) and ...

A retrospective case series found that treatment with an interleukin (IL)-5 inhibitor reduced eosinophil levels and improved clinical outcomes in patients with drug reaction with eosinophilia and ...

Researchers from Aarhus University and Synuca Therapeutics recently presented a novel drug-like small-molecule inhibitor of sarco/endoplasmic reticulum calcium ATPase (SERCA), SYN-4569, with superior ...

“However, pyruvate transport was shown to follow saturation kinetics, to be sensitive to sulfhydryl reagents, and to be abolished by small-molecule inhibitors, supporting the existence of a ...

“Today’s two presentations highlight the unique potential of VG-3927 as an orally bioavailable, highly potent and CNS penetrant small molecule TREM2 agonist and provide the complete dataset ...