Liquids with very low viscosity can leak from two-piece shells soon after filling. Hygroscopic liquids can cause embrittlement in capsule shells. Harris (Juniper): The choice of capsule size and fill ...

Figure 3: Microscopy of unprocessed drug substance ... The allowable fill weights of the unprocessed, roll-compacted and milled, and milled-only drug substances in a given capsule size were determined ...

This guide covers an in-depth analysis of both the capsule filling working process and machines. It is an all-in-one capsule filling machine guide with vital information that will help ...