The G-loop acts like a landing pad for additional proteins. These proteins untie the G4 knot, break apart the G-loop and ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...

Single-Stranded DNA The molecule of the hereditary material deoxyribonucleic acid (DNA) normally consists of two interwoven strands. The discovery of a form with only one strand promises to ...

Recently, Professor Frédéric Veyrier at the Institut national de la recherche scientifique (INRS) and his team developed a new genetic tool based on a family of specific enzymes called Ssn that allows ...

First, they fabricated a universal single-strand DNA, as well as library of hundreds of short, single DNA strands called bricks. Each brick is composed of 24 nucleotides, including cytosine sites ...

An INRS team discovers a new family of enzymes capable of inducing targeted cuts in single-stranded DNA . A few years ago, the advent of technology known as CRISPR was a major breakthrough in the ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the ...

Single-stranded DNA is less common than double-stranded DNA. It is often found in some viruses and plays a key role in certain biological processes, such as cell replication or repair. Single ...

More information: Haichao Zhao et al, Distinct regulation of ATM signaling by DNA single-strand breaks and APE1, Nature Communications (2024). DOI: 10.1038/s41467-024-50836-6 Journal information ...

The team initially set out to study another replication machinery protein, single-stranded DNA-binding protein, and its interaction with DNA polymerase. However, they first needed to establish how the ...