科学家们通过给小鼠使用一种由癌症研究人员开发的药物来激活p53以抑制肿瘤，从而验证了他们的发现。在老年小鼠中，这种药物并没有减少衰老细胞的数量，而是逆转了标记与年龄相关的SASP的细胞特征，有可能阻止导致炎症衰老的炎症污染。

Cellular senescence (CS) marks a crucial cell cycle halt triggered in proliferating cells under various stress conditions, manifesting across different ...

As our bodies grow, cells proliferate to form tissues, and cells frequently have to be repaired or replaced throughout life..

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

Climatic stress events, such as extreme temperatures and prolonged droughts, are increasingly affecting tree growth and ...

Reproduction is a critical biological imperative. If reproduction falls below replacement level, a population declines—and ultimately disappears.

In theory, that means scientists could remove the cause of age-related diseases like Alzheimer's or arthritis by reversing the process of senescence at the cellular level. The body's ageing process is ...

Scientists at Sanford Burnham Prebys and collaborators across the country published findings March 5, 2025, in Nature ...

A study by the National Land Survey of Finland and the University of Helsinki has revealed significant individual differences ...

The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal ...