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本研究针对猪精液性别分选技术成本高、损伤大的问题，开发了特异性靶向Y染色体精子(Y-sperm)质膜表位的单链可变区抗体(scFv)。通过杂交瘤技术获得4D1-E8单克隆抗体(mAb)，进而构建795bp scFv基因并在大肠杆菌中表达。H4:L4 scFv对Y-sperm特异性达100%，与X-sperm交叉反应 ...
该研究开发了一种策略，利用从头设计的结合蛋白（de novo-designed binder，DNDB）代替典型的scFv作为肿瘤表面抗原结合域，以增强CAR-T细胞的抗肿瘤潜力。
CAR元件有多种组分组成。抗体来源的单链可变区（scFv）识别肿瘤表面特异抗原，胞内共刺激分子结构域（如CD28，4-1BB）控制CAR-T细胞增殖、分化和 ...
一些方法，包括替换共刺激模块，优化scFv结构的稳定性，以及缩短连接重链和轻链可变区域的连接体，已经被应用于调整CAR的基底信号。解决这些 ...
Efficacy and safety of first-line treatments for patients with advanced hepatocellular carcinoma: A systematic review and network meta-analysis. This is an ASCO Meeting Abstract from the 2023 ASCO ...
Tumor microenvironment (TME), longitudinal biomarker changes, and clinical outcome in patients (pts) with advanced BRAF V600–mutant melanoma treated with first-line spartalizumab (S) + dabrafenib (D) ...
The single-chain variable fragment (scFv) has the nucleic acid hydrolyzing activity and is shown to degrade DNA or mRNA of viruses in infected cells. “scFv has various advantages over ...
The majority of the reported CART19 trials test the anti-CD19 scFv originated from FMC63, including the four CD19 CARs approved by the FDA. The anti-FMC63 antibody, which specifically identifies ...
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