The sarcomere is subdivided in several regions ... you need to picture its components in their natural environment -- one of the biggest challenges in biological research nowadays that cannot ...

To then understand the contribution of α-actinin-2 to localize FATZ proteins onto the Z-disk of the sarcomere, Sponga et al. transfected GFP-tagged FATZ-1 or FATZ-2 proteins into immortalized ...

dynamic interplay of muscle components moves the muscle in its native environment”, says Raunser. Skeletal and heart muscles contract upon the interaction of two types of parallel protein filaments in ...

Scientists have produced the first high-resolution 3D image of the sarcomere, the basic contractile unit of skeletal and heart muscle cells, using electron cryo-tomography (cryo-ET). The ...