SVec, a replication-defective, non-immunogenic vector, is derived from the macaque polyomavirus SV40. This polyomavirus strictly replicates in macaques where it causes chronic symptomless infections.

“I then purified this plasmid cloning vector that had the gal operon and showed that I could take the purified DNA and reintroduce it back into E. coli using a method that [Stanford biochemist] Dale ...

ATLANTA — The US Institute of Medicine (IOM) is looking into whether polio vaccines contaminated with the simian virus SV40 — thought to inactivate p53 and Rb — and given 40 years ago have caused a ...