The mammalian homologue of Sir2 (SirT1) regulates p53, NF-κB and Forkhead transcription factors, and is implicated in stress response. This report shows that the cell-cycle and apoptosis ...

The protein targets of SIRT1, a sirtuin that has been shown to regulate metabolism and stress response, include transcription factors and cofactors, histones and other chromatin proteins ...

Sirtuin 1 (SirT1) is an essential nutrient-sensing histone deacetylase, which is increased by caloric restriction and reduced by overfeeding. We discovered that SirT1 depletion causes anorexia by ...

Researchers find changes to protein SirT1 Date: January 27, 2014 Source: Boston University Medical Center Summary: Studies have suggested that the protein SirT1 may be protective in metabolic ...

Reducing liver protein SIRT1 levels Date: January 22, 2014 Source: Boston University Medical Center Summary: A new study demonstrates that the abnormal metabolism linked to obesity could be ...

In mammals, SIRT1-SIRT7 have been discovered, among which SIRT1 is the most extensively studied. Although many studies have reported the association of SIRT1 with protection against ...

A healthy low-calorie diet that contains plant products can help us improve the level of sirtuin 1 (SIRT1) protein production that is known to increase life expectancy. A team of scientists from ...

SIRT1 has also been shown to interact with LXR to promote LXR activation. Additionally, previous literature has shown that starvation increases SIRT1 levels in mice. The purpose of this study was to ...

Zooming in on a single gene, a genome-wide association study appearing in 2015 found that a variant of a protein-encoding gene known as Sirtuin1 (SIRT1) correlates with a much higher risk of ...

With a new research paper, the Harvard genetics professor shows how the red wine chemical resveratrol and other compounds directly activate an enzyme called SIRT1, an activity on the target that ...

HO-1 inhibits the activation of the TGF-ß/Smad3 pathway in NAFLD-related liver fibrosis through SIRT1. These findings provide insights into new therapeutic strategies for treating NAFLD ...