Although mutations in mitochondrial DNA (mtDNA ... transfer of mutant mtDNA associated with ROS overproduction significantly increased metastatic potential, so the possibility of ROS scavengers ...

As a result, ROS from overactive mitochondria are frequently cited as a source of DNA damage. Despite this longstanding belief, few studies have explicitly demonstrated this linkage. Tobias Dansen, a ...

To fight this, doctors often use drugs called BRAF inhibitors, such as vemurafenib, which can stop the cancer’s growth—at ...

Human epidermal growth factor receptor 2 (HER2) The human epidermal growth factor receptor 2 (HER2) gene mutation is involved in 1% to 4% of NSCLCs. About 1% to 2% of NSCLCs have the ROS1 mutation.

High levels of CYP2E1 increase the production of DNA-damaging ROS, leading to gene mutations and tumors. ROS also disrupt cell behavior, causing cells to multiply and spread uncontrollably.